Non communicable chronic diseases represent the bulk of morbidity, disability and premature deaths in Europe and account for 75% of the disability-adjusted life years. Among these, cancer represents the second cause of morbidity and mortality worldwide. Differences in the molecular characteristics of the tumor cells as well as differences in patient genetic origin, gender, age, lifestyle and circadian rhythms account for large variability in the time courses of cancer diseases and treatment response.

TEMPO addresses the control of several key dynamic pathways in cancer drug metabolism and cellular proliferation by the circadian timing system. This biological system consists of a network of molecular clocks that times bodily and cellular functions along the 24 hours. Chronotherapeutics aim at the delivery of medications according to the 24-hour rhythms generated by the patient’s molecular clocks in order both to prevent adverse events and to improve overall therapeutic activity CONFERENCE ADDRESSING CHRONOBIOLOGY, FRANCIS LEVI MEMBER OF THE ORGANISATION BOARD

The conference will take place between Wednesday October, 15th and Friday October 17th Venue: International Labour Organisation Training Center, Viale Maestri del Lavoro 10 - Turin, Italy REGISTRATION IS COMPULSORY :NO REGISTRATION FEE REQUIRED The conference is aimed at gathering senior and junior researchers. With a highly interdisciplinary approach and a translational view into diseases and therapeutics, the conference will discuss and foster knowledge, as well as novel approaches and tools to analyze the temporal dimension of biomedical parameters. The conference structure will enable all participants, from whom full involvement in the discussions is expected, to attend every presentations.

The Conference, Oct 15-17 will comprise 5 Plenary lectures, 5 Symposia, 2 Poster Sessions. 2 Satellites meeting, Problems into focus will be held on Wednesday October 15th: 10.30 until 13.00 : What determines sleep duration? Saturday October 18 th:9.00 until 18.40:Genes at work on time in cancer processes and their treatments

Abstract deadline: June 30th Registration deadline: September 15th